石榴皮提取物對大鼠實驗性前列腺炎的影響

時間: 2011-04-15

     探討石榴皮提取物(Pomegranate peel extracts,PPE)對大鼠非細菌性前列腺炎(NBP)和細菌性前列腺炎(CBP)的抑制作用,並通過觀察其對大鼠血清酸性磷酸酶及前列腺組織中鋅(Zn)含量的影響,分析其可能的作用機制。方法:給藥7天后分別向SD大鼠前列腺內注射角叉菜膠和金黃色葡萄球菌製備大鼠非細菌性前列腺炎和細菌性前列腺炎模型,術後2天檢測大鼠前列腺組織卵磷脂小體的密度、白細胞個數、血漿酸性磷酸酶(ACP)活性,前列腺組織勻漿液中鋅含量、丙二醛水平(MDA)、抗氧化能力指數及血漿一氧化氮(NO)的含量。結果:石榴皮提取物可顯著提高前列腺組織中鋅含量、卵磷脂小體密度,降低前列腺組織勻漿液中白細胞個數及血漿酸性磷酸酶活性,並且能提高血漿的抗氧化能力指數。結論:石榴皮提取物對大鼠非細菌性前列腺炎和細菌性前列腺炎的抑制作用可能與改善酸性磷酸酶活性、前列腺組織Zn含量及機體的氧化應激狀態相關.

Effect of Pomegranate Peel Extracts on Experimental Prostatitis Rats

Objective:To investigate the inhibitory effects of Pomegranate peel extracts (PPE)on experimental prostatitis rats. Methods:The Prostatitis model was established by injection of carrageenan and staphylococcus aureus in rat prostate. After 9 days' treatments of PPE,the rats were sacrificed for measurement of the number of white blood cell(WBC), the density of lecithin, the levels of Zn and malondialdehyde (MDA) of prostate. The antioxidant capacity was measured by oxygen radical absorbance capacity (ORAC) assay. The levels of NO and the activity of acid phosphatase (ACP) of plasma were also measured. Results:PPE increased the levels of ORAC in plasma and the density of lecithin and the levels of Zn, decreased the levels of MDA of prostate and the activity of ACP and the number of WBC and adjusted the levels of NO in plasma compared with the prostatitis model group (P 〈0. 05 or P 〈 0. 01 ). Conclusion: PPE can markedly improve the protective function of oxidation resistance, it may involve its regulatory action on anti-oxidation.

更多內容請參考國內最大的最專業的前列腺疾病網站

北京奧康國際醫學研究院前列腺專研中心官方網

上一篇:咪jB不Tl裾
相關文章
評論